Partner 1:
Ospedale
Pediatrico Bambino Gesù-IRCCS (OPBG)
Partner 2:
Latvian
Institute of Organic Synthesis (LIOS)
Partner 3:
FutureSynthesis.
Sp. z o.o. (FS)
Partner 4:
Anses
- Agence nationale de sécurité sanitaire de l’alimentation, de l’environnement
et du travail (ANSES)
Partner 5:
Cancer
Research Institute, Biomedical Research Center SAS
(BMC-SAS)
The project Consortium is a
multidisciplinary research team that includes fully complementary Partners from
five Member States (Italy, France, Poland, Latvia and Slovakia), two
underrepresented countries (Latvia and Slovakia) and one collaborative partner
with own funding (Dr. A.Caporali). The first criterion considered in building
the Consortium has been ensuring a balanced partnership covering the full value
chain deserved by such an ambitious project aiming at increasing the scientific
knowledge and industrial application of nanotechnology-based therapeutic
approaches with a high expected impact on EU and worldwide skin injuries. The
coordinator OPBG group is formed by
chemists, biotechnologists, biologists, bioinformaticians; its host institution
guarantees a network of multidisciplinary medical doctors; LIOS has a wide chemical expertise on iron oxide nanoparticles and
their incorporation into lipid structures (i.e., liposomes). They also
performed derivatization of lipids and are the right complement to OPBG who worked on the derivatization
of dendrimers. The collaboration with Dr. A.Caporali will reinforce the activities on miRNAs, nanogel preparation and wound
healing experiments in in vivo models. ANSES
has expertise in genotoxicology and together with OPBG and BMC-SAS will
complete the in vitro characterization of the prepared nanogels. BMC-SAS will perform in vivo
experiments on mice to assess the nanosafety of hydrogels, whereas OPBG will perform the experiments by
employing CD-1 or JAX mice. One SME will be involved in the preparation of pure
miRNAs to include into the nanogels and in the optimization of the formulation.
The role of the SME will be also crucial in dissemination, training and exploitation of results.
All the project partners have organizational and scientific skills to conduct dissemination activities throughout Europe and Worldwide, thus ensuring a wide visibility of the final results. Each partner is fundamental to the project success and will carry out the specific Tasks strictly compliant with its field of excellence. The integration of knowledge, expertise and technologies amongst the members of the consortium is essential for realizing the objectives of the project and for the efficient translation of these into commercial devices/products for clinical use, ensuring a safe, socially responsible and sustainable approach for skin injuries treatment.
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